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Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling.

Int. Immunopharmacol.. 2018-02; 
NishiyamaKazuhiro,FujitaTakashi,FujimotoYasuyuki,NakajimaHidemitsu,TakeuchiTadayoshi,AzumaYasu-
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud … humidified incubator. 2.5. Establishment of stably transfected cells. For overexpression, cDNA of the murine FATP1, FATP4, and FATP6 genes was cloned into the pcDNA3.1 vector (Genscript Corporation, Piscataway, NJ). RAW264 … Get A Quote

摘要

Macrophages are important cells that need to be controlled at the site of inflammation. Several factors are involved in chronic inflammation and its timely resolution. Free fatty acids drive the inflammatory response in macrophages and contribute to the vicious cycle of the inflammatory response. However, the identity of the uptake pathways of fatty acids is not fully clear in macrophages and how the inflammatory responses are regulated by the uptake of fatty acids remain poorly understood. We investigated the relationship between fatty acid transport protein (FATP) and the inflammatory response signaling pathway in macrophages as the first report. The FATP family has composed six isoforms, FATP1-6. We foun... More

关键词

Ceramide,Fatty acid transport proteins,Inflammation,JNK,Macrop