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A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Δ6-desaturation of omega-3 fatty acids.

Prostaglandins Leukot. Essent. Fatty Acids. 2018-06; 
KothapalliKumar S D,ParkHui Gyu,GuoXiaoxian,SunXuepeng,ZouJames,HyonStephanie S,QinXia,LawrencePeter,Ran-ResslerRinat R,ZhangJi Yao,GuZhenglong,BrennaJ Th
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ORF cDNA Clones/MolecularCloud … PCR products were separated on 2% agarose gels, visualized, gel extracted and sequenced. 2.6. Transfection assay. The ORF synthesis of FADS2AT2 and its cloning into a pcDNA3.1 expression vector was carried-out at GenScript (GenScript USA Inc., NJ) … Get A Quote

摘要

The only known non-pharmacological means to alter long chain polyunsaturated fatty acid (LCPUFA) abundance in mammalian tissue is by altering substrate fatty acid ratios. Alternative mRNA splicing is increasingly recognized as a modulator of protein structure and function. Here we report identification of a novel alternative transcript (AT) of fatty acid desaturase 2 (FADS2) that inhibits production of omega-3 but not omega-6 LCPUFA, discovered during study of ATs in human milk fat globules (MFG).

关键词

Alternative transcript,Desaturase,Elongase,Milk fat globule,Polyunsaturated fatty