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Peptide microarray-based characterization of antibody responses to host proteins after bacille Calmette-Guérin vaccination

Int. J. Infect. Dis.. 2017-03;

ValentiniDavide, RaoMartin, RaneLalit, RahmanSayma, Axelsson-RobertsonRebecca, HeuchelRainer, LöhrMatthias, HoftDaniel, BrighentiSusanna, ZumlaAlimuddin, MaeurerMa

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摘要

Bacille Calmette-Guérin (BCG) is the world's most widely distributed vaccine， used against tuberculosis (TB)， in cancer immunotherapy， and in autoimmune diseases due to its immunomodulatory properties. To date， the effect of BCG vaccination on antibody responses to host proteins has not been reported. High-content peptide microarrays (HCPM) offer a unique opportunity to gauge specific humoral immune responses.