至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Adaptation of vectors and drug-inducible systems for controlled expression of transgenes in the tumor microenvironment

J Control Release. 2017-12; 
PoutouJoanna, BunualesMaria, Gonzalez-AparicioManuela, GermanBeatriz, ZugastiInes, Hernandez-AlcocebaR
Products/Services Used Details Operation
PCR and Cloning … of plasmid fragments. For assembly of the ZP65 transactivator, a sequence comprising the ZFHD1 DBD and the N-terminal portion of the hPR LBD was ordered from GenScript (Piscataway, NJ, USA). These functional domains … Get A Quote

摘要

Biological therapies based on recombinant proteins such as antibodies or cytokines are continuously improving the repertoire of treatments against cancer. However, safety and efficacy of this approach is often limited by inappropriate biodistribution and pharmacokinetics of the proteins when they are administered systemically. Local administration of gene therapy vectors encoding these proteins would be a feasible alternative if they could mediate long-term and controlled expression of the transgene after a single intratumoral administration. We describe a new vector platform specially designed for this purpose. Different combinations of transactivators and promoters were evaluated to obtain a fully humanized... More

关键词