| Products/Services Used | Details | Operation |
|---|---|---|
| Custom RNAi Services | … used as the expression vector. We designed siRNA targeting HBx and CAT-1 mRNAs according to the GenScript siRNA Target Finder (https://www.genscript.com/ssl- bin/app/rnai). The sense and antisense oligonucleotides … | Get A Quote |
The HBx protein of hepatitis B virus (HBV) is widely recognized to be a critical oncoprotein contributing to the development of HBV-related hepatocellular carcinoma (HCC). In addition， cationic amino acid transporter 1 (CAT-1) gene is a target of miR-122. In this study， we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues， and that CAT-1 promoted HCC cell growth， proliferation， and metastasis. Moreover， HBx-induced decreases in Gld2 and miR-122 levels that contributed to the upregulation of CAT-1 in HCC. These results indicate that a Gld2/miR-122/CAT-1 pathway regulated by HBx likely participates in HBV-related hepatocellular ca... More
