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Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the Antitumor Effects of Human TRAIL

Theranostics. 2017-01; 
TaoZe, YangHao, ShiQiuxiao, FanQing, WanLin, LuXiao
Products/Services Used Details Operation
Gene Synthesis … To produce the Z PDGFRβ affibody, the unique C-terminal cysteine residue of Z09591 29 was deleted. An artificial gene encoding the Z PDGFRβ affibody was synthesized by GenScript (Nanjing, China) and cloned into pQE30 to prepare Z PDGFRβ affibody … Get A Quote
Bacterial Expression System Get A Quote

摘要

Human tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL) has exhibited superior cytotoxicity in a variety of tumor cells. However, hTRAIL showed a disappointing anticancer effect in clinical trials, although hTRAIL-based regimens were well tolerated. One important reason might be that hTRAIL was largely trapped by its decoy receptors, which are ubiquitously expressed on normal cells. Tumor-targeted delivery might improve the tumor uptake and thus enhance the antitumor effect of hTRAIL. Platelet-derived growth factor receptor β (PDGFRβ)-expressing pericytes are enriched in tumor tissues derived both from patients with colon cancer and from mice bearing colorectal tumor xenografts. A Z affi... More

关键词

Affibody,Cancer therapy.,Drug delivery,Pericyte,Platelet-derived growth factor receptor,Tumor necrosis factor-related apoptosis inducing li