Secreted frizzled-related protein 1 (SFRP1) expression is down-regulated in a multitude of cancers， including breast cancer. Loss of Sfrp1 also exacerbates weight gain as well as inflammation. Additionally， loss of SFRP1 enhances TGF-β signaling and the downstream MAPK pathway. TGF-β has been shown to increase the expression of Early Growth Response 2 (EGR2)， a transcription factor implicated in immune function in a wide variety of cell types. The work described here was initiated to determine whether SFRP1 modulation affects TGF-β mediated EGR2 expression in mammary tissues as well as macrophage polarization.
Secreted frizzled-related protein 1 (SFRP1) expression is down-regulated in a multitude of cancers， including breast cancer. Loss of Sfrp1 also exacerbates weight gain as well as inflammation. Additionally， loss of SFRP1 enhances TGF-β signaling and the downstream MAPK pathway. TGF-β has been shown to increase the expression of Early Growth Response 2 (EGR2)， a transcription factor implicated in immune function in a wide variety of cell types. The work described here was initiated to determine whether SFRP1 modulation affects TGF-β mediated EGR2 expression in mammary tissues as well as macrophage polarization.
