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Kisspeptin-10 inhibits OHSS by suppressing VEGF secretion.

Reproduction. 2017-10; 
ZhaiJunyu, LiuJiansheng, ZhaoShigang, ZhaoHan, ChenZi-Jiang, DuYanzhi, LiWei
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Biochemicals … In the OHSS + Kp-10 group, the management was same as the OHSS group except that the animals were given 30 IU hCG and 40 nmol Kp-10 (intravenous) (GenScript, Nanjing, China) together on day 5. In the control group, the 24-day-old rats were pretreated with 10 IU PMSG … Get A Quote

摘要

The aim of the present study was to elucidate the effects of kisspeptin-10 (Kp-10) on ovarian hyperstimulation syndrome (OHSS) and its related mechanism in OHSS rat models, human umbilical vein endothelial cells (HUVECs) and human luteinized granulosa cells. OHSS is a systemic disorder with high vascular permeability (VP) and ovarian enlargement. KISS1R (KISS1 receptor) is the specific receptor of kisspeptin. The kisspeptin/KISS1R system inhibits the expression of vascular endothelial growth factor (VEGF), which is the main regulator of VP. In our study, decreased expression of Kiss1r was observed in both ovaries and lung tissue of OHSS rats. Injection of exogenous Kp-10 inhibited the increase of VP and V... More

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