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Identification and characterization of the BmCyclin L1-BmCDK11A/B complex in relation to cell cycle regulation.

Cell Cycle. 2017-05; 
LiuTai-Hang, WuYun-Fei, DongXiao-Long, PanCai-Xia, DuGuo-Yu, YangJi-Gui, WangWei, BaoXi-Yan, ChenPeng, PanMin-Hui, LuC
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Custom RNAi Services … thermofisher.com/rnaiexpress/setOption. do?designOptionDmirnaandpidD77956 43179598091088) and synthesized by GenScript Corporation (Nanjing, China) as described previously.34 Cell transient transfection BmNS cells at … Get A Quote

摘要

Cyclin proteins are the key regulatory and activity partner of cyclin-dependent kinases (CDKs), which play pivotal regulatory roles in cell cycle progression. In the present study, we identified a Cyclin L1 and 2 CDK11 2 CDK11 splice variants, CDK11A and CDK11B, from silkworm, Bombyx mori. We determined that both Cyclin L1 and CDK11A/B are nuclear proteins, and further investigations were conducted to elucidate their spatiofunctional features. Cyclin L1 forms a complex with CDK11A/B and were co-localized to the nucleus. Moreover, the dimerization of CDK11A and CDK11B and the effects of Cyclin L1 and CDK11A/B on cell cycle regulation were also investigated. Using overexpression or RNA interference ... More

关键词

Bombyx mori,CDK11,NLS,cell cycle,cycli