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Expression of the VP1 protein of FMDV integrated chromosomally with mutant Listeria monocytogenes strain induced both humoral and cellular immune responses.

Appl. Microbiol. Biotechnol.. 2019-03; 
MahdyS E, LiuSijing, SuLin, ZhangXiang, ChenHaotai, PeiXiaofang, WangC
Products/Services Used Details Operation
PCR and Cloning … MK050946). It is provided by the company fused with pUC57 plasmid. Provided by GenScript company (China) pCW108 Containing XbaI, NotI, and SpeI single sites, AmpR and EryR fragment (Wang et al. 2014) pCW203 Containing HindIII and XhoI single sites (Wang et al … Get A Quote

摘要

Live vector-based vaccine is a modern approach to overcome the drawbacks of inactivated foot-and-mouth disease (FMD) vaccines such as improper inactivation during manufacture. Listeria monocytogenes (LM), an intracellular microorganism with immune-stimulatory properties, is appropriate to be utilized as a live bacterial vaccine vector. FMDV-VP1 protein has the capability to induce both cellular and humoral immune responses since it is considered the most immunogenic part of FMDV capsid and has the most of antigenic sites for viral neutralization. The codon-optimized vp1 gene was ligated to the integrative pCW702 plasmid to construct the target cassette. The antigen cassette was integrated successfully into ... More

关键词

FMD,Listeria,Recombinant,VP1,Vector vac