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Aripiprazole and haloperidol protect neurite lesions via reducing excessive D2R-DISC1 complex formation.

Prog. Neuropsychopharmacol. Biol. Psychiatry. 2018-12; 
ZhengPeng, HuMinmin, XieYuanyi, YuYinghua, Jaaro-PeledHanna, HuangXu-
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Gene Synthesis … The D2R-EGFP, D2R mutant-EGFP and DISC1-mCheery coding sequences were synthesized by GenScript (GenScript, Hong Kong Ltd) and sub-cloned into the pcDNA3 vector … D2R-Flag plasmid is from Sino Biological Incorporation (Beijing, China) … Get A Quote
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摘要

Dopamine D2 receptor (D2R) hyperactivity causes altered brain development and later produces onset of symptoms mimicking schizophrenia. It is known that D2R interacts with disrupted in schizophrenia 1 (DISC1); however, the effect of D2R-DISC1 interaction in intracellular signalling and neurite growth has not been studied. This study investigated the effect of D2R over-activation on Akt-GSK3β signalling and neurite morphology in cortical neurons. Over-activation of D2Rs caused neurite lesions, which were associated with decreased protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK3β) phosphorylation in cortical neurons. The antipsychotic drug aripiprazole was more effective in the prevention of... More

关键词

Antipsychotic drug,D2 receptor,D2R-DISC1 complex,GSK3β,Neurite gr