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Type 3 inositol 1,4,5-trisphosphate receptor has antiapoptotic and proliferative role in cancer cells.

Cell Death Dis. 2019-03; 
RezuchovaIngeborg, HudecovaSona, SoltysovaAndrea, MatuskovaMiroslava, DurinikovaErika, ChovancovaBarbora, ZuzcakMichal, CihovaMarina, BurikovaMonika, PenesovaAdela, LencesovaLubomira, BrezaJan, Krizanova
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Custom DNA/RNA Oligos … 17,18 . Lentiviral transfer plasmids pLCS-ITPR3-1 and pLCS-ITPR3-2 (GenScript, USA) contained a lentiCRISPRv2 backbone and single above-mentioned oligos cloned into the single guide RNA (sgRNA) scaffold. To make … Get A Quote

摘要

Although the involvement of type 1 (IPR1) and type 2 (IPR2) inositol 1,4,5-trisphosphate receptors in apoptosis induction has been well documented in different cancer cells and tissues, the function of type 3 IPR (IPR3) is still elusive. Therefore, in this work we focused on the role of IPR3 in tumor cells in vitro and in vivo. We determined increased expression of this receptor in clear cell renal cell carcinoma compared to matched unaffected part of the kidney from the same patient. Thus, we hypothesized about different functions of IPR3 compared to IPR1 and IPR2 in tumor cells. Silencing of IPR1 prevented apoptosis induction in colorectal cancer DLD1 cells, ovarian cancer A2780 cells, and clear... More

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