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Targeting of a Photosensitizer to the Mitochondrion Enhances the Potency of Photodynamic Therapy.

ACS Omega. 2018; 
MahalingamSakkarapalayam M,OrdazJosue D,LowPhil
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Biochemicals 2-(1H-7-Azabenzotriazol-1-yl)- 1,1,3,3-tetramethyl uronium hexafluorophosphate methanaminium (HATU) was obtained from Genscript Inc. ( Get A Quote

摘要

Photodynamic therapy (PDT) involves use of a photosensitizer, whose activation with light leads to the production of singlet oxygen (SOS), generation of reactive oxygen species (ROS), and initiation of associated cell toxicity. Because a cell's mitochondria constitute sites where oxygen levels are high, ROS can be readily produced, and apoptosis is commonly initiated. Therefore, an ideal PDT agent might be a potent photosensitizer that could naturally accumulate in mitochondria. Although a number of mitochondria-targeting moieties, including triphenylphosphine, guanidinium, and bisguanidium, have been identified, a quantitative comparison of their efficacies in targeting mitochondria has n... More

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