资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer.

J. Exp. Clin. Cancer Res.. 2017;

LingZhixin，WangXiaoyan，TaoTao，ZhangLei，GuanHan，YouZonghao，LuKai，ZhangGuangyuan，ChenShuqiu，WuJianping，QianJinke，LiuHui，XuBin，Chen

Products/Services Used	Details	Operation
PCR Cloning and Subcloning	The promoter region of has-miR-193a was chemically synthesised and cloned into the KpnI andHindIII restriction sites by GenScript (Nanjing, China), which is downstream the open reading frame of luciferase in the pGL3-basicVector (Promega, Madison, WI, USA) to generate the pGL3-miR-193a promoter reporter.	Get A Quote

摘要

Though androgen deprivation therapy is the standard treatment for prostate cancer (PCa)， most patients would inevitably progress to castration-resistant prostate cancer (CRPC) which is the main cause of PCa death. Therefore， the identification of novel molecular mechanism regulating cancer progression and achievement of new insight into target therapy would be necessary for improving the benefits of PCa patients. This study aims to study the function and regulatory mechanism of HOTAIR/EZH2/miR-193a feedback loop in PCa progression.