资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Bardet-Biedl syndrome obesity: BBS4 regulates cellular ER stress in early adipogenesis.

Mol. Genet. Metab.. 2019; 
AnosovMariana，Birk
Products/Services Used Details Operation
PCR Cloning and Subcloning … 2.2. Short-interfering RNA-mediated Knock-down. In order to knock down BBS4, constructs were designed to express short hairpin interfering RNA (shiRNA) and were cloned by GenScript into p.RANT-H1/neo vector (Genscript, USA) as described previously [18] … Get A Quote

摘要

Bardet-Biedl syndrome (BBS) is an autosomal recessive ciliopathy， presenting with early obesity onset. The etiology of BBS obesity involves both central and peripheral defects， through mechanisms mostly yet to be deciphered. We previously showed BBS4 expression in adipogenesis， peaking at day 3 of differentiation. Obesity is characterized by cellular stress which promotes pathological consequences.

关键词

Adipogenesis，BBS4，Endoplasmic reticulum (ER)，Unfolding protein response (UPR)，X
Article Link >