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Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.

J. Lipid Res.. 2019; 
WonKyoung-Jae，ParkJoo-Seop，JeongHyuny
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PCR Cloning and Subcloning … Luciferase activity was measured using GloMax luminometer (Promega) and normalized to the Renilla luciferase activity. Lentiviral infection. Flag-tagged CYP7A1 clone was purchased from Genscript. Coding region of Flag … Get A Quote

摘要

- retinoic acid (atRA) is used to treat certain cancers and dermatologic diseases. A common adverse effect of atRA is hypercholesterolemia; cytochrome P450 (CYP) 7A repression is suggested as a driver. However， the underlying molecular mechanisms remain u

关键词

cholesterol metabolism，cytochrome P450，nuclear receptors，retinoids/vitamin A，toxico
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