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Natural Killer Cells may Exert Antidepressant-like Effects in Mice by Controlling the Release of Inflammatory Factors.

Neuroscience. 2019; 
HuLirong,LiDongping,GeChuang,LiaoHong,WangYing,XuHa
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DNA Sequencing … Afterward, we conducted a ligation reaction between the digested plasmids and oligo DNA using the follow reaction system: 5 … The amplified plasmids were sequenced by GenScript Biotech Corporation (Nanjing, China, order number: C0106BK100, C6158BK140, C7329BK160 … Get A Quote

摘要

Depression or stress is reportedly related to the overflow of inflammatory factors in the body and T cells were reported to play important roles in balancing the release of inflammatory factors through vagus nerve circuit. However, few works have been conducted to find if natural killer (NK) cells can also exert the similar function in the reported vagus nerve circuit as T cells and if there was any relationship between depression and this function. In the present study, the behavioral tests on BALB/c mice indicated that the depressant-like symptoms could be improved and simultaneously the concentrations of inflammatory factors in peripheral blood could be reduced significantly by adoptively transferring NK... More

关键词

NK cells,behavioral tests,depression,inflammatory factors,β(2)-adrenergic rece