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Integrating scFv into xMAP Assays for the Detection of Marine Toxins

Toxins (Basel). 2016-11; 
Shriver-Lake LC, Liu JL, Brozozog Lee PA, Goldman ER, Dietrich R, Märtlbauer E, Anderson GP
Products/Services Used Details Operation
Bacterial Expression System We contracted with Genscript (Piscataway, NJ, USA) to have the variable regions of the mAbs sequenced as well as for the production of each mAb for evaluation. Get A Quote

摘要

Marine toxins, such as saxitoxin and domoic acid are associated with algae blooms and can bioaccumulate in shell fish which present both health and economic concerns. The ability to detect the presence of toxin is paramount for the administration of the correct supportive care in case of intoxication; environmental monitoring to detect the presence of toxin is also important for prevention of intoxication. Immunoassays are one tool that has successfully been applied to the detection of marine toxins. Herein, we had the variable regions of two saxitoxin binding monoclonal antibodies sequenced and used the information to produce recombinant constructs that consist of linked heavy and light variable domains that m... More

关键词

domoic acid; saxitoxin; single chain antibody; xMAP