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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Nat Commun. 2018-08; 
Pardi N, Parkhouse K, Kirkpatrick E,, McMahon M, Zost SJ, Mui BL, Tam YK, Karikó K, Barbosa CJ, Madden TD, Hope MJ, Krammer F, Hensley SE, Weissman D
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Bacterial Expression System mRNAs were produced as previously described41 using T7 RNA polymerase (Megascript, Ambion) on linearized plasmids (synthesized by GenScript) encoding … Get A Quote

摘要

Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgently needed. The highly conserved influenza virus hemagglutinin (HA) stalk represents one of the potential targets of broadly protective/universal influenza virus vaccines. Here, we evaluate a potent broadly protective influenza virus vaccine candidate that uses nucleoside-modified and purified mRNA encoding full-length influenza virus HA formulated in lipid nanoparticles (LNPs). We demonstrate that immunization with HA mRNA-LNPs induces antibody... More

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