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Construction, expression and Evaluation of Recombinant VP2 protein for serotype-independent Detection of FMDV seropositive Animals in egypt

Sci Rep. 2019-07; 
Salem R, El-Kholy AA, Omar OA, Abu El-Naga MN, Ibrahim M, Osman G
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Bacterial Expression System The coding sequence of this protein was modified and codon optimized for expression in E. coli. The modified sequence was synthesized by GenScript, Piscataway, NJ, USA. Get A Quote

摘要

Foot-and-mouth disease virus (FMDV) is one of the most devastating viral pathogens of cloven-hoofed animals. The detection of antibodies (Ab) against FMDV structural proteins (SP) using virus neutralization test (VNT) and liquid-phase blocking ELISA (LPBE) is the standard procedure in use for monitoring seroconversion in animals post vaccination, the prevalence of infection-surveillance, proving clinical cases and seronegative status of FMDV-free/naïve-animals prior transportation. However, due to variations within SP of FMDV serotypes, each serotype-specific Ab should be detected separately which is laborious and time-consuming. Accordingly, it is crucial to develop a sensitive, rapid, and accurate test capab... More

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