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Evaluation of the Antifungal and Wound Healing Properties of a Novel Peptide-Based Bioadhesive Hydrogel Formulation

Antimicrob Agents Chemother. 2019-07; 
Sultan AS, Vila T, Hefni E, Karlsson AJ, Jabra-Rizk MA
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Mutant Libraries Peptide hydrogel formulation. Hst-5 and the K11R-K17R peptide (Table 1) were 117 synthesized by GenScript (Piscataway, NJ) with ≥95% purity. The double-mutant 118 K11R-K17R peptide was … Get A Quote

摘要

Oral candidiasis (OC) caused by the fungal pathogen Candida albicans is the most common opportunistic infection in immunocompromised populations. The dramatic increase in resistance to common antifungal agents has emphasized the importance of identifying alternative therapeutic options. Antimicrobial peptides have emerged as promising drug candidates due to their antimicrobial properties; specifically, histatin-5 (Hst-5), a peptide naturally produced and secreted by human salivary glands, has demonstrated potent activity against C. albicans However, as we previously demonstrated vulnerability for Hst-5 to proteolysis by C. albicans proteolytic enzymes at specific amino-acid residues, a new variant (K11R-K17R) w... More

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