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Activation of vitamin D regulates response of human bronchial epithelial cells to Aspergillus fumigatus in an autocrine fashion.

Mediators Inflamm.. 2015; 
LiPei,WuTing,SuXin,S
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Immunoassay Development Services … All primers were synthesized by GenScript (Nanjing, China) 26 Quantitative Determination of 1,25D 3 1,25D 3 was quantified using an enzyme immunoassay kit for 1,25D 3 (Immunodiagnostic Systems, Boldon, UK) according to the manufacturer's instructions 27 … Get A Quote

摘要

Aspergillus fumigatus (A. fumigatus) is one of the most common fungi to cause diseases in humans. Recent evidence has demonstrated that airway epithelial cells play an important role in combating A. fumigatus through inflammatory responses. Human airway epithelial cells have been proven to synthesize the active vitamin D, which plays a key role in regulating inflammation. The present study was conducted to investigate the impact of A. fumigatus infection on the activation of vitamin D and the role of vitamin D activation in A. fumigatus-elicited antifungal immunity in normal human airway epithelial cells. We found that A. fumigatus swollen conidia (SC) induced the expression of 1α-hydroxylase, the enzyme c... More

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