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Sequential and competitive adsorption of peptides at pendant PEO layers.

Colloids Surf B Biointerfaces. 2015-06; 
WuXiangming,RyderMatthew P,McGuireJoseph,SniderJoshua L,SchilkeKa
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摘要

Earlier work provided direction for development of responsive drug delivery systems based on modulation of the structure, amphiphilicity, and surface density of bioactive peptides entrapped within pendant polyethylene oxide (PEO) brush layers. In this work, we describe the sequential and competitive adsorption behavior of such peptides at pendant PEO layers. Three cationic peptides were used for this purpose: the arginine-rich, amphiphilic peptide WLBU2, a peptide chemically identical to WLBU2 but of scrambled sequence (S-WLBU2), and the non-amphiphilic peptide poly-L-arginine (PLR). Optical waveguide lightmode spectroscopy (OWLS) was used to quantify the rate and extent of peptide adsorption and el... More

关键词

Cationic amphiphilic peptides,Competitive adsorption,PEO brush,Polyarginine,Sequential adsorption,W