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Tomato I2 Immune Receptor Can Be Engineered to Confer Partial Resistance to the Oomycete Phytophthora infestans in Addition to the Fungus Fusarium oxysporum.

Mol. Plant Microbe Interact.. 2015; 
GiannakopoulouArtemis,SteeleJohn F C,SegretinMaria Eugenia,BozkurtTolga O,ZhouJi,RobatzekSilke,BanfieldMark J,PaisMarina,KamounSop
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Mutagenesis Services … 2002) was used as destination for the mutagenized I2 sequences The R3a I148N clone with a single-residue mutation (I148N) was obtained by GenScript Site-Directed Mutagenesis Service, as described previously (Segretin et al 2014) … Get A Quote

摘要

Plants and animals rely on immune receptors, known as nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins, to defend against invading pathogens and activate immune responses. How NLR receptors respond to pathogens is inadequately understood. We previously reported single-residue mutations that expand the response of the potato immune receptor R3a to AVR3a(EM), a stealthy effector from the late blight oomycete pathogen Phytophthora infestans. I2, another NLR that mediates resistance to the will-causing fungus Fusarium oxysporum f. sp. lycopersici, is the tomato ortholog of R3a. We transferred previously identified R3a mutations to I2 to assess the degree to which the resulting I... More

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