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The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.

PLoS ONE. 2015; 
ZizzariIlaria Grazia,MartufiPaola,BattistiFederico,RahimiHassan,CaponnettoSalvatore,BellatiFilippo,NutiMarianna,RughettiAurelia,NapoletanoCh
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Recombinant Antibody Services … analysis software (Becton Dickinson) Binding of rhMGL to Tregs and competition assay The human recombinant MGL protein (rhMGL-Fc) was synthesised by GenScript USA Inc (Piscataway, NJ, USA) It contains the extracellular … Get A Quote

摘要

Regulatory T cells (Tregs) are physiologically designed to prevent autoimmune disease and maintain self-tolerance. In tumour microenvironments, their presence is related to a poor prognosis, and they influence the therapeutic outcome due to their capacity to suppress the immune response by cell-cell contact and to release immunosuppressive cytokines. In this study, we demonstrate that Treg immunosuppressive activity can be modulated by the cross-linking between the CD45RA expressed by Tregs and the C-type lectin MGL. This specific interaction strongly decreases the immunosuppressive activity of Tregs, restoring the proliferative capacity of co-cultured T lymphocytes. This effect can be attributed to cha... More

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