A β2-microglobulin (β2m) fragment that lacks the first six amino acids， i.e.， ΔN6β2-microglobulin (ΔN6β2m)， is an endogenous， proteolytically derived， amyloidogenic fragment of β2m， the precursor protein in Aβ2M amyloidosis (dialysis-related amyloidosis). As reports suggest the importance of C-terminal unfolding for the amyloidogenicity of β2m， in this study we aimed to investigate conformational characteristics of ΔN6β2m related to amyloidogenicity. We also measured the concentration of an amyloidogenic intermediate of β2m with C-terminal unfolding (β2m92-99) in serum samples from 10 patients undergoing hemodialysis (HD).
A β2-microglobulin (β2m) fragment that lacks the first six amino acids， i.e.， ΔN6β2-microglobulin (ΔN6β2m)， is an endogenous， proteolytically derived， amyloidogenic fragment of β2m， the precursor protein in Aβ2M amyloidosis (dialysis-related amyloidosis). As reports suggest the importance of C-terminal unfolding for the amyloidogenicity of β2m， in this study we aimed to investigate conformational characteristics of ΔN6β2m related to amyloidogenicity. We also measured the concentration of an amyloidogenic intermediate of β2m with C-terminal unfolding (β2m92-99) in serum samples from 10 patients undergoing hemodialysis (HD).
