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DEK over-expression promotes mitotic defects and micronucleus formation.

Cell Cycle. 2015; 
MatrkaMarie C,HenniganRobert F,KappesFerdinand,DeLayMonica L,LambertPaul F,AronowBruce J,WellsSusan
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Biochemicals Doxycline was added to media for the indicated times at 1 ug/ml. The MIEG-His-Flag-DEK (GenScript Piscataway, NJ) Get A Quote

摘要

The DEK gene encodes a nuclear protein that binds chromatin and is involved in various fundamental nuclear processes including transcription, RNA splicing, DNA replication and DNA repair. Several cancer types characteristically over-express DEK at the earliest stages of transformation. In order to explore relevant mechanisms whereby DEK supports oncogenicity, we utilized cancer databases to identify gene transcripts whose expression patterns are tightly correlated with that of DEK. We identified an enrichment of genes involved in mitosis and thus investigated the regulation and possible function of DEK in cell division. Immunofluorescence analyses revealed that DEK dissociates from DNA in early prophase a... More

关键词

DEK,aneuploidy,cancer,chromosome instability,micronuclei,mitosis,mitotic def