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CodY Regulates the Activity of the Virulence Quorum Sensor PlcR by Controlling the Import of the Signaling Peptide PapR in Bacillus thuringiensis.

Front Microbiol. 2015; 
SlamtiLeyla,LemyChristelle,HenryCéline,GuillotAlain,HuilletEugénie,LereclusDi
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Biochemicals Synthetic PapR7 (ADLPFEF) and PapR27 (DTAFEKSQIISHNDQEVQVAADLPFEF) were ordered from Genscript at a purity >95% and were resuspended in water. Get A Quote

摘要

In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors of the RNPP family. Activity of these regulators depends on their binding to secreted signaling peptides that are imported into the cell. These quorum sensing regulators control important biological functions in bacteria of the Bacillus cereus group, such as virulence and necrotrophism. The RNPP quorum sensor PlcR, in complex with its cognate signaling peptide PapR, is the main regulator of virulence in B. cereus and Bacillus thuringiensis (Bt). Recent reports have shown that the global stationary phase regulator CodY, involved in adaptation to nutritional limitation, is required for the expression of virulence g... More

关键词

Opp,mass spectrometry,quorum-sensing,regulation,shot gun,signaling peptide,virulence reg