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Sperm-Coating Beta-Defensin 126 Is a Dissociation-Resistant Dimer Produced by Epididymal Epithelium in the Bovine Reproductive Tract.

Biol. Reprod.. 2016-04; 
NarciandiFernando,Fernandez-FuertesBeatriz,KhairulzamanIlaina,JahnsHanne,KingDeirdre,FinlayEmma K,MokKen H,FairSean,LonerganPatrick,FarrellyCliona O',MeadeKier
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Monoclonal Antibody Services A custom monoclonal antibody specific for BBD126 (a-BBD126) was commercially generated by Genscript using a standard protocol. Get A Quote

摘要

Beta-defensins are innate immune molecules, often described as antimicrobial peptides because of their bactericidal activity and are now known to have diverse additional functions, including cell signaling, chemoattraction, immunoregulation, and reproduction. In humans and primates, beta-defensin 126 has been shown to regulate the ability of sperm to swim through cervical mucus and to protect sperm from attack by the female immune system during transit toward the oviduct. Bovine beta-defensin 126 (BBD126) is the ortholog of human defensin 126, and computational analysis here revealed significant conservation between BBD126 and other mammalian orthologs at the N-terminus, although extensive seque... More

关键词

bovine,epididymis,β-defensin