至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Synergistic effects of hyaluronate - epidermal growth factor conjugate patch on chronic wound healing.

Biomater Sci. 2016-06; 
KimYun Seop,SungDong Kyung,KongWon Ho,KimHyemin,HahnSei K
Products/Services Used Details Operation
Recombinant Antibody Services … 2.1 Materials. Sodium hyaluronate (HA) with a molecular weight (MW) of 200 kDa was purchased from Lifecore Biomedical (Chaska, MN). Recombinant human EGF was obtained from Genscript (Piscataway, NJ). Sodium periodate … Get A Quote

摘要

The proteolytic microenvironment in the wound area reduces the stability and the half-life of growth factors in vivo, making difficult the topical delivery of growth factors. Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells. After the synthesis of HA-EGF conjugates, they were incorporated into a patch-type formulation for the facile topical application and sustained release of EGF. According to ELISA, the HA-EGF conjugates showed a long-term stability compared with native EGF. Furthermore, HA-EGF conjugates appeared to... More

关键词