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Gold NanoBipyramids Performing as Highly Sensitive Dual-Modal Optical Immunosensors.

Anal. Chem.. 2016-07; 
CampuAndreea,LerougeFrederic,ChateauDenis,ChaputFrederic,BaldeckPatrice,ParolaStephane,ManiuDana,CraciunAna Maria,VulpoiAdriana,AstileanSimion,FocsanMo
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Biochemicals … Cardiac Troponin I (cTnI) was purchased from GenScript (USA). The zeta potential was measured on a Zetasizer Nano (Malvern). SERS measurements were collected on a Thermo Scientific DXR Raman confocal microscope with a 532 nm laser … Get A Quote

摘要

In this work, we demonstrate the feasibility of gold bipyramidal-shaped nanoparticles (AuBPs) to be used as active plasmonic nanoplatforms for the detection of the biotin-streptavidin interaction in aqueous solution via both Localized Surface Plasmon Resonance and Surface Enhanced Raman Scattering (LSPR/SERS). Our proof of concept exploits the precise attachment of the recognition element at the tips of AuBPs, where the electromagnetic field is stronger, which is beneficial to the surface sensitivity of longitudinal LSPR on the local refractive index and to the electromagnetic enhancement of SERS activity, too. Indeed, successive red shifts of the longitudinal LSPR associated with increased local refr... More

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