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Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice.

BMC Cancer. 2016-12; 
ChienChia-Hung，LeeMing-Jen，LiouHoung-Chi，LiouHorng-Huei，FuWen
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Cellular Analysis … B16F10 cells (5 × 10 3 cells) were seeded on 96-well plates and incubated overnight in RPMI medium supplemented with 10 % FBS. The medium was then replaced with serum-free medium containing GH (0.5, 5, and 15 ng/ml; GenScript, Piscataway, USA) … Get A Quote

摘要

Growth hormone (GH) mainly serves an endocrine function to regulate somatic growth， but also serves an autocrine function in lung growth and pulmonary function. Several recent studies have demonstrated the role of autocrine GH in tumor progression in some organs. However， it is not clear whether excessive secretion of GH in the lungs is related to pulmonary nodule formation.

关键词

Growth hormone，Knockout mice，Lung metastasis，Melanoma，Oncogen
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