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PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance.

Pharm. Res.. 2016-12;

ReichardEmily E，Nanaware-KharadeNisha，GonzalezGuillermo A，ThakkarShraddha，OwensS Michael，PetersonEr

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Bacterial Expression System	… 36). cDNA encoding scFv7F9Cys was synthesized by GenScript (Piscataway, NJ) and cloned into a pUC57 vector (14,36,37). For maintenance the plasmids were transformed into E. coli strain DH5α (Invitrogen, Carlsbad, CA) …	Get A Quote

摘要

Methamphetamine (METH) abuse is a worldwide drug problem， yet no FDA-approved pharmacological treatments are available for METH abuse. Therefore， we produced an anti-METH single chain antibody fragment (scFv7F9Cys) as a pharmacological treatment for METH abuse. ScFv's have a short half-life due to their small size， limiting their clinical use. Thus， we examined the pharmacokinetic effects of conjugating poly(ethylene) glycol (-PEG) to scFv7F9Cys to extend its functional half-life.