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New poly(ester-amide) copolymers modified with polyether (PEAE) for anticancer drug encapsulation.

J Microencapsul. 2016-08; 
Chudecka-GłazAnita,SzczeblińskaJoanna,Cymbaluk-PłoskaAneta,KohnJoachim,El FrayMiros
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Biochemicals … Gouda, The Netherlands). N-(3-dimethylaminopropyl)-NL-ethylcarbodiimide hydrochloride (EDC·HCl) was obtained from GenScript Biology CRO for Drug Discovery (GenScript USA Inc., Piscataway, NJ). Other chemicals such … Get A Quote

摘要

New poly(ester-amide) copolymers modified with polyethers were developed for carboplatin encapsulation. These new copolymers contain hydrophobic blocks made of tyrosine derivative and dimer fatty acid, and poly(ethylene glycol) (PEG) as hydrophilic blocks. Short-term hydrolytic degradation revealed high water absorption, slight increase of pH of simulated body fluid and change of sample shape, which indicated the erosive mechanism of polymers degradation. Poly(ester-amide)-PEG copolymers were used for microspheres preparation and carboplatin encapsulation. A double emulsification process was used to produce microspheres with an average diameter of 20-30 μm. It was found that the amount of drug released... More

关键词

Biodegradable polymers,drug release,microencapsulation,polymer synth