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Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes.

Nat Commun. 2016;

BacosKarl，GillbergLinn，VolkovPetr，OlssonAnders H，HansenTorben，PedersenOluf，GjesingAnette Prior，EibergHans，TuomiTiinamaija，AlmgrenPeter，GroopLeif，EliassonLena，VaagAllan，DayehTasnim，LingCharl

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摘要

Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors， aged 26-74 years. Aging associates with increased DNA methylation of 241 sites. These sites cover loci previously associated with T2D， for example， KLF14. Blood-based epigenetic biomarkers reflect age-related methylation changes in 83 genes identified in human islets (for example， KLF14， FHL2， ZNF518B and FAM123C) and some associate with insulin secret... More