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Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance.

J Transl Med. 2016;

ParkMi-Kyung，JungYoung Ok，LeeSeon-Yeong，LeeSeung Hoon，HeoYu-Jung，KimEun-Kyung，OhHye-Jwa，MoonYoung-Mee，SonHye-Jin，ParkMin-Jung，ParkSung-Hwan，KimHo-Youn，ChoMi-La，MinJu

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Mammalian Expression System	… form of a graph. Transfection of CD19 + B cells. The Foxp3 open reading frame (ORF) was codon optimized for mammalian codon usage and was synthesized by Genscript Corp. (Piscataway, NJ, USA). The Foxp3 ORF was …	Get A Quote

摘要

Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs)， and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expressing Foxp3 may play a role in preventing the development of collagen-induced arthritis (CIA) in DBA/1J mice.