| Products/Services Used | Details | Operation |
|---|---|---|
| Biochemicals | Sodium hydroxide was purchased from Fisher Scientific (Pittsburg, PA, USA). (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5- b]pyridinium 3-oxid hexafluorophosphate) (HATU) was purchased from GenScript (Piscataway, NJ, USA). | Get A Quote |
The modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein， we describe a new class of structure-specific nucleic acid junction stabilizers based on a triptycene scaffold. Triptycenes provide significant stabilization of DNA and RNA three-way junctions， providing a new scaffold for the development of nucleic acid junction binders with enhanced recognition properties. Additionally， we report cytotoxicity and cell uptake data in two human ovarian ca... More
