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Deletion of IL-4R α in the BALB/c mouse is associated with altered lesion topography and susceptibility to experimental autoimmune encephalomyelitis

Journal Autoimmunity. 2014; 
Jacqueline M. Orian, Paula Keating, Leana L. Downs, Matthew W. Hale, Xiangrui Jiang, Hong Pham
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Biochemicals … Mice, aged between 8 and 14 weeks, were immunized sc in the rear flanks with 100 μg/mouse PLP180–199 (GenScript, Piscataway, NJ) emulsified in CFA supplemented with 500 μg/ mouse Mycobacterium tuberculosis H37Ra (Difco, Lawrence, KS) … Get A Quote

摘要

The regulation of cytokine expression by immune deviation from a pro-inflammatory to anti-inflammatory or “regulatory” milieu is crucial to the prevention of permanent central nervous system (CNS) damage in neuroinflammation.

关键词

Atypical EAE, cerebellar lesions, cortical lesions, EAE-resistant variant, multiple sclerosis, neuropathology
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