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Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease.

Gastroenterology. 2019;

HøydahlLene Støkken，RichterLisa，FrickRahel，SnirOmri，GunnarsenKristin Støen，LandsverkOle J B，IversenRasmus，JeliazkovJeliazko R，GrayJeffrey J，BergsengElin，FossStian，QiaoShuo-Wang，LundinKnut E A，JahnsenJørgen，JahnsenFrode L，SandlieInger，SollidLudvig M，LøsetGeir

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PCR Cloning and Subcloning	… 19 The construct encoding HLA-DQ2.5:DQ2.5-glia-α1a-Sα72I was generated by cloning a BglII/BamHI codon-optimized synthetic DNA fragment (Genscript, Piscataway, NJ) encoding the HLA-DQ2.5 α-chain (DQA1*05:01) with the Sα72I mutation into the pMIG-II-eGFP retroviral …	Get A Quote

摘要

Development of celiac disease is believed to involve the transglutaminase-dependent response of CD4 T cells toward deamidated gluten peptides in the intestinal mucosa of individuals with specific HLA-DQ haplotypes. We investigated the antigen presentation process during this mucosal immune response.