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The mouse intron-nested gene, Israa, is expressed in the lymphoid organs and involved in T-cell activation and signaling.

Mol. Immunol.. 2019; 
Ben KhalafNoureddine,Al-MashoorWedad,SaeedAzhar,Al-MehatabDalal,TahaSafa,BakhietMoiz,FathallahM Dah
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Monoclonal Antibody Services … Cell lysates were incubated with 10 μg of mouse anti-ISRAA monoclonal antibody developed by GenScript (GenScript, NJ, USA) overnight at 4 °C then with Pierce™ Protein A/G Magnetic Beads (Thermo Fisher Scientific, MA, USA) for 1 h at room temperature … Get A Quote

摘要

We have previously reported Israa, immune-system-released activating agent, as a novel gene nested in intron 8 of the mouse Zmiz1 gene. We have also shown that Israa encodes for a novel FYN-binding protein and might be involved in the regulation of T-cell activation. In this report, we demonstrate that Israa gene product regulates the expression of a pool of genes involved in T-cell activation and signaling. Real time PCR and GFP knock-in expression analysis showed that Israa is transcribed and expressed in the spleen mainly by CD3CD8 cells as well as in the thymus by CD3 (DP and DN), CD4SP and CD8SP cells at different developmental stages. We also showed that Israa is downregulated in T-cells following... More

关键词

Elf1,Fyn,Gene expression,Nested gene,T-cell activation,Yeast two-hy