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miR-125a-5p: a novel regulator of SLC26A6 expression in intestinal epithelial cells.

Am. J. Physiol., Cell Physiol.. 2019; 
AnbazhaganArivarasu N,PriyamvadaShubha,BorthakurAlip,SaksenaSeema,GillRavinder K,AlrefaiWaddah A,DudejaPrade
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Mutagenesis Services … miR-125a-5p binding seed sequence of PAT-1-3´UTR with 135 Page 6. 6 desired mutations was custom synthesized by GenScript (Figure 6) and mutations confirmed 136 by sequencing. The primer sets used for site-directed mutagenesis are listed in Table 1. 137 … Get A Quote

摘要

Putative anion transporter 1 (PAT1, SLC26A6), an intestinal epithelial Cl/ exchanger, also plays a key role in oxalate homeostasis via mediating intestinal oxalate secretion. Indeed, Slc26a6-null mice showed defect in intestinal oxalate secretion and high incidence of kidney stones. Recent emergence of PAT-1 as a novel therapeutic target for nephrolithiasis warrants detailed understanding of the mechanisms of PAT-1 regulation in health and disease. Therefore, we investigated the regulation of PAT-1 expression by microRNAs (miRNA), as they have been shown to play key role in modulating expression of other ion transporters. In silico analysis of PAT-1 3'-untranslated region (UTR) revealed potential b... More

关键词

PAT1,hyperoxaluria,microRNA,nephrolithiasis,oxalate secre