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Melatonin receptors in Atlantic salmon stimulate cAMP levels in heterologous cell lines and show season-dependent daily variations in pituitary expression levels.

J. Pineal Res.. 2019; 
CianiElia,FontaineRomain,MaugarsGersende,MizrahiNaama,MayerIan,Levavi-SivanBerta,WeltzienFinn-
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PCR Cloning and Subcloning … mtnr1aaβ, mtnr1ab, and mtnr1b inserted into pcDNA3.1 (Invitrogen, Waltham, USA) were obtained from GenScript Biotech (Piscataway, USA) based on sequence information retrieved from GenBank and verified by cloning and sequencing (see PCR primers in … Get A Quote

摘要

The hormone melatonin connects environmental cues, such as photoperiod and temperature, with a number of physiological and behavioural processes, including seasonal reproduction, through binding to their cognate receptors. This study reports the structural, functional and physiological characterization of five high-affinity melatonin receptors (Mtnr1aaα, Mtnr1aaβ, Mtnr1ab, Mtnr1al, Mtnr1b) in Atlantic salmon. Phylogenetic analysis clustered salmon melatonin receptors into three monophyletic groups, Mtnr1A, Mtnr1Al and Mtnr1B, but no functional representative of the Mtnr1C group. Contrary to previous studies in vertebrates, pharmacological characterization of four receptors in COS-7... More

关键词

daily expression,melatonin receptors,pharmacology,phylogeny,pituitary,sexual maturation,signalling pat