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Cold chain and virus-free oral polio booster vaccine made in lettuce chloroplasts confers protection against all three poliovirus serotypes.

Plant Biotechnol. J.. 2019; 
DaniellHenry,RaiVineeta,XiaoYu
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Molecular Biology Tools … The codon-optimized sequence of VP1 was synthesized by GenScript, Piscataway, NJ … accession number AY184219; 906 bp) was codon optimized (VP1co) using the in-house tool (Kwon et al., 2016) and synthesized by GenScript, Piscataway, NJ. The VP1co and native … Get A Quote

摘要

To prevent vaccine-associated paralytic poliomyelitis, WHO recommended withdrawal of Oral Polio Vaccine (Serotype-2) and a single dose of Inactivated Poliovirus Vaccine (IPV). IPV however is expensive, requires cold chain, injections and offers limited intestinal mucosal immunity, essential to prevent polio reinfection in countries with open sewer system. To date, there is no virus-free and cold chain-free polio vaccine capable of inducing robust mucosal immunity. We report here a novel low-cost, cold chain/poliovirus-free, booster vaccine using poliovirus capsid protein (VP1, conserved in all serotypes) fused with cholera non-toxic B subunit (CTB) expressed in lettuce chloroplasts. PCR using un... More

关键词

Polio viral protein 1,bioencapsulation,human infectious diseases,lettuce chloroplast transformation,mucosal immunity,oral deli