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Transient Expression in Islets During Pregnancy Correlates With β-Cell Survival, Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus.

Diabetes. 2019; 
Martin-MontalvoAlejandro,López-NoriegaLivia,Jiménez-MorenoCarmen,HerranzAmanda,LorenzoPetra I,Cobo-VuilleumierNadia,TamayoAlejandra,González-GuerreroCristian,HofsteedeJonathan S W R,LebretonFanny,BoscoDomenico,García ToscanoMiguel,HerranzLucrecia,AnselmoJoao,MorenoJosé Carlos,GauthierBeno
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Mutagenesis Services Site-directed mutagenesis (GenScript, Piscataway Township, NJ) was performed on the human PAX8 cDNA to generate mutant variants PAX8-P25R and PAX8-T356M . Get A Quote

摘要

Transient expression was reported in mouse islets during gestation, whereas a genome-wide linkage and admixture mapping study highlighted as a candidate gene for diabetes mellitus (DM). We sought the significance of PAX8 expression in mouse and human islet biology. was induced in gestating mouse islets and in human islets treated with recombinant prolactin. Global gene expression profiling of human and mouse islets overexpressing the corresponding species-specific PAX8 revealed the modulation of distinct genetic pathways that converge on cell survival. Accordingly, apoptosis was reduced in PAX8-overexpressing islets. These findings support that could be a candidate gene for the study of gestational DM (... More

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