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The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth.

J Thorac Oncol. 2011;

SchmidtLars Henning，SpiekerTilmann，KoschmiederSteffen，SchäffersSonja，HumbergJulia，JungenDominik，BulkEtmar，HascherAntje，WittmerDanielle，MarraAlessandro，HillejanLudger，WiebeKarsten，BerdelWolfgang E，WiewrodtRainer，Muller-TidowCar

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DNA Sequencing	… Specificity of the shRNA sequences was verified by BLAST search. A nonrelated 21 nt sequence was used as a negative shRNA control (“scrambed shRNA,” Table 1). For shRNA expression, pRNAT-H1.1/Neo (Genscript Corp company, Piscataway, NJ) was used …	Get A Quote

摘要

The functions of large noncoding RNAs (ncRNAs) have remained elusive in many cases. Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) is an ncRNA that is highly expressed in several tumor types.