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Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples.

AAPS J. 2017; 
LoebrichSven,ShenMingfang,CohenErika,PayneGillian,ChenYing,BogalhasMegan,ZhaoY
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摘要

Antibody-drug-conjugates (ADCs) are an emerging class of biological therapeutics. Mirvetuximab soravtansine is a novel folate receptor alpha (FRα)-targeting ADC which represents a potential new treatment for patients with ovarian and other FRα-positive cancers. Since patient immune responses to biological therapeutics may negatively affect drug efficacy and patient safety, regulatory authorities require rigorous monitoring of patient samples. Taking advantage of the immune system's ability to generate highly specific antibodies, the field has turned to anti-idiotype antibodies as powerful tools for the development of sensitive and specific bioassays. Here, we report the generation and characterization o... More

关键词

Anti-idiotype,Antibody-drug-conjugate,Antidrug-antibody,Immunogenicity,Neutralizing anti