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Loss of miR-217 promotes osteosarcoma cell proliferation through targeting SETD8.

Pharmazie. 2018; 
YangGuangshi,WangJiefeng,HuangB
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud China). ORF construct for SETD8 (SETD8 construct) and NC were purchased from GenScript (Nanjing Get A Quote

摘要

Recently, many kinds of microRNAs (miRNAs) have been found to play a critical role in progression of osteosarcoma (OS). miR-217 was reported to function as a tumor suppressor in a number of human cancers but its precise mechanism to exert the suppressive role remains to be investigated. In this study, we found that miR-217 was downregulated in OS tissues and its downregulation predicts poor overall survival of OS patients. Importantly, we found that a lower expressed miR-217 in OS cell lines inhibited the cell proliferation and invasion . By bioinformatic analysis, we found that miR-217 targeted the SET Domain-Containing Protein 8 (SETD8), and there was a negative correlation between them in OS tissue... More

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