至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

A pannexin 1 channelopathy causes human oocyte death.

Sci Transl Med. 2019-03; 
SangQing,ZhangZhihua,ShiJuanzi,SunXiaoxi,LiBin,YanZheng,XueSongguo,AiAi,LyuQifeng,LiWei,ZhangJilin,WuLing,MaoXiaoyan,ChenBiaobang,MuJian,LiQiaoli,DuJing,SunQiang,JinLi,HeLin,ZhuShujia,KuangYanping,Wan
Products/Services Used Details Operation
Nucleic Acid Purification & Analysis Oligo donors with 123–base pair (bp) (for Q392*, C347S, and K346E) or 100-bp (for 21_23delTEP) homology to sequences on both sides of the mutation site were obtained as ultramer DNA oligos from GenScript Corporation. Get A Quote

摘要

Connexins and pannexins are two protein families that play an important role in cellular communication. Pannexin 1 (PANX1), one of the members of pannexin family, is a channel protein. It is glycosylated and forms three species, GLY0, GLY1, and GLY2. Here, we describe four independent families in which mutations in cause familial or sporadic female infertility via a phenotype that we term "oocyte death." The mutations, which are associated with oocyte death, alter the PANX1 glycosylation pattern, influence the subcellular localization of PANX1 in cultured cells, and result in aberrant PANX1 channel activity, ATP release in oocytes, and mutant PANX1 GLY1. Overexpression of a patient-deri... More

关键词