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Cutaneous Human Polyomavirus Small T Antigens and 4E-BP1 Targeting.

Intervirology. 2015; 
WuJulie H,SimonetteRebecca A,HsiaoThomas,DoanHung Q,RadyPeter L,TyringSteph
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Monoclonal Antibody Services HEK293 cells were infected with the lentiviral constructs; expression of the sT antigen was confirmed by Western blotting with the appropriate custom mouse monoclonal antibodies (GenScript Inc). Get A Quote

摘要

Merkel cell polyomavirus (MCPyV), trichodysplasia spinulosa-associated polyomavirus (TSPyV), human polyomavirus 6 (HPyV6), and human polyomavirus 7 (HPyV7) are implicated in the pathogeneses of distinct hyperproliferative cutaneous growths and encode small tumor (sT) antigens. The current study demonstrates that the four sT antigens differentially regulate 4E-binding protein 1 (4E-BP1) serine 65 hyperphosphorylation. MCPyV and HPyV7 sT antigens were found to promote the presence of the hyperphosphorylated 4E-BP1-δ isoform, while TSPyV and HPyV6 sT antigens had no significant effects. Given that hyperphosphorylated 4E-BP1 is associated with an aggressive cancer phenotype, our findings confirm the prev... More

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