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The influence of opioid dependence on salt consumption and related psychological parameters in mice and humans.

Drug Alcohol Depend. 2019-08;

SmithCraig M，GarfieldJoshua B B，AttawarAparna，LubmanDan I，LawrenceAndr

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摘要

The consumption of dietary salt (NaCl) is controlled by neuronal pathways that are modulated by endogenous opioid signalling. The latter is disrupted by chronic use of exogenous opioid receptor agonists， such as morphine. Therefore， opioid dependence may influence salt consumption， which we investigated in two complimentary studies in humans and mice.